PENGARUH VITAMIN E TERHADAP KADAR SGPT DAN SGOT TIKUS PUTIH GALUR WISTAR YANG DIPAPAR TIMBAL
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Abstract
This study aimed to examine the effect of the vitamin E administration on levels of SGOT and SGPT blood serum male albino rats (Rattus norvegicus) wistar strain were exposed of lead per oral. The sample used 20 male rats were divided into 4 groups:I of a control, II of the treatment of lead 175 mg/rat, III of Vitamin E 1.44 mg/rat and lead 175 mg/rat, IV of Vitamin E 2.16 mg/rat and lead 175 mg/rat for 21 days. On day 22 measured levels of SGOT and SGPT and blood lead. SGOT and SGPT data were analyzed with one-way ANOVA, followed by BNT test. The results of one-way ANOVA showed antioxidant vitamin E giving a significant effect on the levels of SGOT and SGPT (p <0.05) rats. The BNT test SGOT levels showed a significant difference except in group II and III, the SGPT levels showed a significant difference except in group III and IV. From the results of this study concluded that the affects of vitamin E decrase levels of SGOT and SGPT blood serum of male albino rats (Rattus norvegicus) wistar strain were exposed to lead per oral.
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References
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Sipos P, Szentmihaly K, Feher E & AbazaM. 2003. Some Effect of Lead Contamination on Liver and Gallblader Bile. Acta Biologica Szegebdiensis. 47(1-4) : 139-142.
Casado MF, Cecchini AL, Simao ANC, Oliveira RD & Cecchini R. 2007. Free Radical-mediated Pre-hemolytic Injuri in Human Blood Cells Subjected to Lead Asetat as Evaluated by Chemiluminescence. Food and chemical Toxicology. Vol 45(6) : 945-952
Dedy S. 2008. Pengaruh Proteksi Vitamin C Terhadap Enzim Transaminase dan Gambaran Histopatologi Hati Mencit yang di Papar Plumbum (Tesis). Sumatra Utara: Universitas Sumatra8 Utara.
Gajawat S, Sancheti G & Goyal PK. 2006. Protection Against Lead Induced Hepatic Lesion in Swiss Albino Mice by absorbis Acid. Pharmologionline. 1 :140-149.
Gurer H & Ercal N. 2000. Can antioksidan be Benefical in The treatmen of lead Posioning? Free Radic Biol Med. 29(10): 927-945.
Hariyatmi. 2004. Kemampuan vitamin E sebagai antioksidan terhadap radikal bebas pada usia lanjut. Jurnal MIPA UMS. 14 : 52-60.
Mostafa MH, Osfor, Ibrahim HS, Mohamed YA, Ahamed SM, Azeem ASAE, & Hegazy AM. 2010. Effect of Alpha Acid and Vitamin E on Heavy Metals Intoxication in Male Albino Rats. Journal of America Science. 6(8) : 56-63.
Nirmalida S. 2004. Bahaya Pencemaran Timbal Pada Minuman dan Makanan (Skripsi). Jurusan Biologi Universitas Lambung Mangkurat.
Pala FS & Kiymet T. 2007. Free radical : Our Enemies or friends ?. Advances in Molecular Biology. (1) : 63-69
Palar H. 1994. Pencemaran dan Toksikologi Logam Berat. Jakarta : Rineka Cipta.
Patrick L. 2006. Lead Toxicity Part II: The Role of Free Radical Damage and the Use of Antioxidants in the Pathology and Treatment of Lead Toxicity. Alternative Medicine Review. 11(2) : 114-127.
Sipos P, Szentmihaly K, Feher E & AbazaM. 2003. Some Effect of Lead Contamination on Liver and Gallblader Bile. Acta Biologica Szegebdiensis. 47(1-4) : 139-142.