The Effect of Creatine Monohydrate Consumption on Men's Cognitive Function with Anaerobic Exercise
DOI:
https://doi.org/10.15294/jssf.v11i2.27491Keywords:
creatine , memory , weightliftingAbstract
Introduction: Creatine monohydrate is a supplement used to accelerate the recovery process, increase muscle mass, and affect the cognitive function of its consumer. Objectives: This study aimed to determine the effect of consuming creatine monohydrate on male cognitive function with anaerobic exercise. Method: The methodology used in this study is by conducting experiments involving 12 participants aged between 20-45 years old with anaerobic exercise routines. The participants were asked to consume creatine monohydrate 5 gr/day for 20 days. Assessment of cognitive function was conducted on day 0 and day 21 using the XpressO by MoCA instrument, and the data were analyzed using a dependent paired t-test. Result: The average age, weight, height, and body mass index of the participants were 31.2±7.6 years old, 80.9±14.6kg, 170.6±5.1cm, and 27.8kg/m2 respectively. Significant increase in cognitive function on day 21 compared to day 0 was shown respectively by 46.75±9.8 and 32.33±9.7 (p=0.024; p<0.05). Conclusion: Creatine monohydrate consumption with a dose 5 gr/day for 20 days has an effect on the increase of male cognitive function with anaerobic exercise.
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Astorino T , Baker J, Brock S, Dalleck L, Goulet E, G. R. (2020). Effect of 16 weeks of strength training and creatine supplementation on strength and cognition in older adults: A pilot study. Journal of Exercise Physiology, 16(3), 84.
Bamberger, M. (1998). The magic potion. Sports Illustrated 88.
Benton, D., & Donohoe, R. (2011). The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. British Journal of Nutrition, 105(7), 1100–1105. https://doi.org/10.1017/S0007114510004733
Borchio L, Machek SB, M. M. (2020). Supplemental creatine monohydrate loading improves cognitive function in experienced mountain bikers. The Journal of sports medicine and physical fitness. The Journal of Sports Medicine and Physical Fitness, 60(8), 1168–1170.
Buchanan, Mackenzie, et al. "Physical activity promotion among individuals with tetralogy of Fallot." CJC Pediatric and Congenital Heart Disease 2.6 (2023): 322-334.
Buford, T. W., Kreider, R. B., Stout, J. R., Greenwood, M., Campbell, B., Spano, M., ... & Antonio, J. (2007). International Society of Sports Nutrition position stand: creatine supplementation and exercise. Journal of the International Society of Sports Nutrition, 4(1), 6.
Ciesielska, N., Sokołowski, R., Mazur, E., Podhorecka, M., Polak-Szabela, A., & Kȩdziora-Kornatowska, K. (2016). Czy test Montreal Cognitive Assessment (MoCA) moze być skuteczniejszy od powszechnie stosowanego Mini-Mental State Examination (MMSE) w wykrywaniu łagodnych zaburzeń funkcji poznawczych u osób po 60. roku zycia? Metaanaliza. Psychiatria Polska, 50(5), 1039–1052. https://doi.org/10.12740/PP/45368
Cournot, M.C.M.J., Marquie, J.C., Ansiau, D., Martinaud, C., Fonds, H., Ferrieres, J. and Ruidavets, J.B., 2006. Relation between body mass index and cognitive function in healthy middle-aged men and women. Neurology, 67(7), pp.1208-1214.
de Guingand, D. L., Palmer, K. R., Snow, R. J., Davies-Tuck, M. L., & Ellery, S. J. (2020). Risk of adverse outcomes in females taking oral creatine monohydrate: A systematic review and meta-analysis. Nutrients, 12(6), 1–26. https://doi.org/10.3390/nu12061780
Depkes RI. 2009. Undang-undang nomor 36 tahun 2009 tentang kesehatan indonesia.
Dolan, E., Gualano, B., & Rawson, E. S. (2019). Beyond muscle: the effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury. European Journal of Sport Science, 19(1), 1–14. https://doi.org/10.1080/17461391.2018.1500644
Forbes, S. C., Cordingley, D. M., Cornish, S. M., Gualano, B., Roschel, H., Ostojic, S. M., Rawson, E. S., Roy, B. D., Prokopidis, K., Giannos, P., & Candow, D. G. (2022). Effects of creatine supplementation on brain function and health. Nutrients, 1–16.
Ismail M CT. (2000). Redefining obesity and its treatment. Geneva, Switzerland: World Health Organization. 8–45.
Julayanont, P., Phillips, N., Chertkow, H., & Nasreddine, Z. S. (2013). Montreal cognitive assessment (MoCA): concept and clinical review. In A practical approach.
Kalman, D. S., Hohl, C., Petersen, B., Flynn, S., Evans, C., Antonio, J., & Tartar, J. (2021). A Randomized Double-Blind Evaluation of the Gastrointestinal, Body Composition, Stress Response and Cognitive Function Impacts of Creatine Supplementation in Healthy Adults. EC Nutrition, 16(11), 19–28. https://www.researchgate.net/publication/355944338
Klil‐Drori S, Bodenstein KC, Sun S, Kojok L, Gruber J, Ghantous Y, Cummings J, N. Z. (2024). Montreal cognitive assessment (MoCA) xpresso: validation of a digital self-administered cognitive prescreening tool. Journal of the American Geriatrics Society, 1–7.
Kreider, R. B., Jäger, R., & Purpura, M. (2022). Bioavailability, efficacy, safety, and regulatory status of creatine and related compounds: A critical review. Nutrients, 14(1035), 3–51.
Li, Z., Wang, P., Yu, Z., Cong, Y., Sun, H., Zhang, J., Zhang, J., Sun, C., Zhang, Y., & Ju, X. (2015). The effect of creatine and coenzyme Q10 combination therapy on mild cognitive impairment in parkinson’s disease. European Neurology, 73(3–4), 205–211. https://doi.org/10.1159/000377676
McMorris, T., Mielcarz, G., Harris, R. C., Swain, J. P., & Howard, A. (2007). Creatine supplementation and cognitive performance in elderly individuals. Aging, Neuropsychology, and Cognition, 14(5), 517–528. https://doi.org/10.1080/13825580600788100
Merege-Filho CA, Otaduy MC, de Sá-Pinto AL, de Oliveira MO, de Souza Gonçalves L, Hayashi AP, Roschel H, Pereira RM, Silva CA, Brucki SM, da C. L. C. (2017). Does brain creatine content rely on exogenous creatine in healthy youth? A proof_of-principle study. Applied Physiology, Nutrition, and Metabolism, 45(2), 1–25.
Metzl, J. D., Small, E., Levine, S. R., & Gershel, J. C. (2001). Creatine use among young athletes. Pediatrics, 108(2), 421–425. https://doi.org/10.1542/peds.108.2.421
Momtaz, Y.A., Haron, S.A., Hamid, T.A., Ibrahim, R. and Tanjani, P.T., 2018. Body mass index (BMI) and cognitive functions in later life. Current Alzheimer Research, 15(2), pp.195-200.
O’Driscoll, C., & Shaikh, M. (2017). Cross-cultural applicability of the montreal cognitive assessment (MoCA): A systematic review. Journal of Alzheimer’s Disease, 58(3), 789–801. https://doi.org/10.3233/JAD-161042
Rae, C., Digney, A. L., McEwan, S. R., & Bates, T. C. (2003). Oral creatine monohydrate supplementation improves brain performance: A double-blind, placebo-controlled, cross-over trial. Proceedings of the Royal Society B: Biological Sciences, 270(1529), 2147–2150. https://doi.org/10.1098/rspb.2003.2492
Reports, 360 Research. (2024). Global creatine market by manufacturers, regions, type and application, forecast. https://www.360researchreports.com/global-creatine-market-13813514
Roelands B, Pluym B, Tassignon B, Verschueren JO, M. R. (2020). Can creatine combat the mental fatigue-associated decrease in visuomotor skills? In Medicine and Science in Sports and Exercise (Vol. 52, Issue 1).
Sandkühler, J. F., Kersting, X., Faust, A., Königs, E. K., Altman, G., Ettinger, U., Lux, S., Philipsen, A., Müller, H., & Brauner, J. (2023). The effects of creatine supplementation on cognitive performance—a randomised controlled study. BMC Medicine, 21(1), 1–16. https://doi.org/10.1186/s12916-023-03146-5
Solis Y, M., De Salles Painelli, V., Artioli, G. G., Roschel, H., Otaduy, M. C., & Gualano, B. (2014). Brain creatine depletion in vegetarians? A cross-sectional 1H-magnetic resonance spectroscopy (1H-MRS) study. British Journal of Nutrition, 111(7), 1272–1274. https://doi.org/10.1017/S0007114513003802
Solis, M.Y., Artioli, G.G., Otaduy, M.C.G., Leite, C.D.C., Arruda, W., Veiga, R.R. and Gualano, B., 2017. Effect of age, diet, and tissue type on PCr response to creatine supplementation. Journal of Applied Physiology, 123(2), pp.407-414.
Toniolo, R. A., Fernandes, F. de B. F., Silva, M., Dias, R. da S., & Lafer, B. (2017). Cognitive effects of creatine monohydrate adjunctive therapy in patients with bipolar depression: Results from a randomized, double-blind, placebo-controlled trial. Journal of Affective Disorders, 224, 69–75. https://doi.org/10.1016/j.jad.2016.11.029
Turner, C. E., Byblow, W. D., & Gant, N. N. (2015). Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation. Journal of Neuroscience, 35(4), 1773–1780. https://doi.org/10.1523/JNEUROSCI.3113-14.2015


