The Effect of Monosodium Glutamate on the Lee Index in Mice (Mus Musculus)

Nurul Innayah(1), Mahalul Azam(2), Ari Yuniastuti(3),




(1) Universitas Negeri Semarang
(2) Universitas Negeri Semarang
(3) Universitas Negeri Semarang

Abstract

Obesity is the buildup of abnormal or excessive fat that can be detrimental to health. High flavor-flavoring consumption or monosodium glutamate (MSG) is one of the factors contributing to the increase in obesity of the Indonesian population. This study aims to analyze the effect of MSG on giving to Lee's index in mice. The Lee index is one of the indicators in determining mice obesity. The type of research was pure laboratory experimental research, with the design Post Test Only Control Group. The mice were divided into four random clusters. Each cluster contained six mice. The control cluster was given standard feed + drink, cluster I was given standard feed + drink + MSG 10.4 mg / 20gbb, cluster II was given standard feed + drink + MSG 20.8 mg / 20gbb and cluster III was given standard feed + drink + MSG 26 mg / 20gbb for 28 days. Day 29 was the weight lift and the length to calculate the lee index. Data normality analyze used Spahiro Wilk and the homogeneity test used Levene's test. The results of the variance homogeneity test showed that the value of p = 0.374, so that the lee index value of each cluster did not have a significant difference (p> 0.05). Then continued with the One Way Anova test, the value of p = 0.246 (meaningful if p <0.05). It could be concluded that the provision of MSG 4 grams, 8 grams, and 10 grams did not have a significant effect on the lee index value in mice between the control cluster and the treatment cluster.

Keywords

Obesity, lee index, mice, monosodium glutamate

Full Text:

PDF

References

Agustin, P. S., & Pertiwi, P. S. (2019). Pengaruh Pola Makan Tidak Seimbang dan Kurangnya Aktivitas Fisik Menyebabkan Terjadinya Obesitas. OSF.

Bera, T. K. (2017). Effects of Monosodium Glutamate (MSG) on Human Health: A Systematic Review. World Journal of Pharmaceutical Sciences, May, 1–7.

Boonnate, P., Waraasawapati, S., Hipkaeo, W., Pethlert, S., Sharma, A., Selmi, C., Prasongwattana, V., & Cha’on, U. (2015). Monosodium glutamate dietary consumption decreases pancreatic β-cell mass in adult Wistar rats. PLoS ONE, 10(6), 1–14.

Dahlan, S. (2015). Statistik Untuk Kedokteran dan Kesehatan (6th ed.). Jakarta: Epidemiologi Indonesia.

Dewantari, N. M. (2013). Peranan Gizi Dalam Kesehatan Reproduksi. Jurnal Skala Husada, 10 Nomor 2.

Dhara, S., & Chatterjee, K. (2015). A Study of VO 2 max in Relation with Body Mass Index (BMI) of Physical Education Students. Research Journal of Physical Education Sciences, 3(6), 9–12.

Hernández-Bautista, R. J., Alarcón-Aguilar, F. J., Escobar-Villanueva, M. D. C., Almanza-Pérez, J. C., Merino-Aguilar, H., Fainstein, M. K., & López-Diazguerrero, N. E. (2014). Biochemical alterations during the obese-aging process in female and male monosodium glutamate (MSG)-treated mice. International Journal of Molecular Sciences, 15(7), 11473–11494.

Ismail, N. H. (2012). Assessment of DNA damage in testes from young Wistar male rat treated with monosodium glutamate. Life Science Journal, 9, 930–939.

Kazmi, Z., Fatima, I., Perveen, S., & Malik, S. S. (2017). Monosodium glutamate: Review on clinical reports. International Journal of Food Properties, 20(2), 1807–1815.

Kristianingrum, S. (2012). Dampak Penggunaan BMT Untuk Minuman. Jurnal Universitas Negeri Yogyakarta.

Kurdanti, W., Suryani, I., Syamsiatun, N. H., Siwi, L. P., Adityanti, M. M., Mustikaningsih, D., & Sholihah, K. I. (2015). Faktor-faktor yang mempengaruhi kejadian obesitas pada remaja. Jurnal Gizi Klinik Indonesia, 11(4), 179.

Kurtanty, D., Faqih, D. M., & Upa, N. P. (2019). Review Monosodium Glutamat How to Understand it Properly? In Journal of Chemical Information and Modeling (Fourth, Vol. 53, Issue 9). Ikatan Dokter Indonesia.

Lee, S.-I., Kim, J.-W., Lee, Y.-K., Yang, S.-H., Lee, I.-A., Suh, J.-W., & Kim, S.-D. (2011). Anti-obesity Effect of Monascus pilosus Mycelial Extract in High Fat Diet-induced Obese Rats. Journal of Applied Biological Chemistry, 54(3), 197–205.

Listiyana, A. D., & Mardiana, G. N. P. (2013). Obesitas Sentral Dan Kadar Kolesterol Darah Total. KESMAS - Jurnal Kesehatan Masyarakat, 9(1), 37–43.

Mardiati, S. M., & Sitasiwi, A. J. (2016). Pertambahan Berat Badan Mencit (Mus musculus L.) Setelah Perlakuan Ekstrak Air Biji Pepaya (Carica papaya Linn.) Secara Oral Selama 21 Hari. Buletin Anatomi Dan Fisiologi, 1(1), 75.

Muslikhah. (2014). Pengaruh Ekstrak Etanol Daun Widuri (Calotropis gigantea) Terhadap Gambaran Histologis Fibrosarkoma Pada Mencit Jantan (Mus Muscullus) Yang Diinduksi 7,12-Dimetilbenza(A)Antrasena (DMBA) Secara In Vivo. Etheses of Maulana Malik Ibrahim State Islamic University.

Putri, F. M. S. (2018). Urgensi Etika Medis Dalam Penanganan Mencit Pada Penelitian Farmakologi. Jurnal Kesehatan Madani Medika, 9(2), 51–61.

Riskesdas, K. (2018). Hasil Utama Riset Kesehata Dasar (RISKESDAS). Journal of Physics A: Mathematical and Theoretical, 44(8), 1–200.

Riwidikdo, H. (2012). Statistik Kesehatan. Jakarta: Mitra Cendikia Press.

Salam, A. (2010). Faktor Risiko Kejadian Obesitas Pada Remaja. Jurnal MKMI, 6(3), 185–190.

Schienkiewitz, A., Mensink, G., Kuhnert, R., & Lange, C. (2017). Overweight and obesity among adults in Germany. Journal of Health Monitoring, 2(2), 20–27.

Stevani, H. (2016). Praktikum Farmakologi. In Modul Bahan Ajar Cetak Farmasi (p. 6). Jakarta: Kementrian Kesehatan Republik Indonesia Direktorat Jenderal Pelayanan Kesehatan.

Thasia, P. (2017). Pengaruh Pemberian Monosodium Glutamat terhadap Kejadian Obesitas pada Mencit. Repositori Institusi USU, 1–85.

Thu Hien, V. T., Thi Lam, N., Cong Khan, N., Wakita, A., & Yamamoto, S. (2013). Monosodium glutamate is not associated with overweight in Vietnamese adults. Public Health Nutrition, 16(5), 922–927.

Tobi, H. AL. (2019). Masak Sehat dengan Bumbu Penyedap (MSG). Jakarta: Gramedia.

Wasilah, F. W. (2016). Pengaruh Pemberian MSG ( Monosodium Glutamat ) Terhadap Kadar Ureum dan Kreatinin Serum (Fungsi Ginjal) pada Tikus Betina Sprague dawley Usia 8-12 Minggu. Institutional Repository UIN Syarif Hidayatullah Jakarta, 60.

WHO. (2015). World Health Statistics 2015. In Bandile, Unathi Cordelia (pp. 2–4).

Widyalita, E. (2014). Analisis Kandungan Monosodium Glutamate (MSG) Pada Pangan Jajanan Anak di SD Komp, Lariangbangi Makassar. Jurnal Fakultas Kesehatan Masyarakat Universitas Hasanudin Makassar.

Refbacks

  • There are currently no refbacks.


View My Stats