Analysis of Factors Affecting CD4+ Increase in HIV / AIDS Patients Receiving ARV Therapy

Dini Wurnaning Budi, RR. Sri Ratna Rahayu, Ari Yuniastuti

Abstract


Acquired immunodeficiency syndrome (AIDS) is a collection of symptoms and infections that arise due to damage to the human immune system due to infection with the Human Immunodeficiency Virus (HIV). The number of HIV patients at Panti Wilasa Hospital continues to increase from every year in 2018 the number is 150 HIV / AIDS patients. The purpose of this study was to analyze the factors that influence the increase in CD4+ levels of HIV / AIDS patients receiving ARV therapy at Panti Wilasa Citarum and Dr. Cipto Hospitals Semarang. This research is a quantitative study, with a cross-sectional approach. The minimum sample of the study was 38 respondents using simple random sampling technique. Data analysis in this study using Multiple Logistic Regression. The results of the study, the most influential variables were clinical stage (p=0.000), and concomitant disease tuberculosis (p = 0.14) on the increase in CD4+ levels. The risk of HIV / AIDS transmission in Indonesia is the highest and until now, there is no cure for HIV. ARV therapy can inhibit the development of the HIV virus, giving ARVs is given if the CD4+ level is less than 500 cells / mm3, or there are other conditions in HIV patients. The importance of early awareness in ARV therapy for early initiation of ARVs is proven to be clinically beneficial, useful for prevention, increase life expectancy and reduce the incidence of HIV-related infections.

Keywords


increase in CD4 +, HIV / AIDS ARVtherapy

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References


Adiningsih, S., Widiyanti, M., Natalia, E. I., & Wahyuni, T. (2018). CD4+ dan Faktor yang Mempengaruhi Kepatuhan Terapi Antiretroviral dengan HIV/AIDS di Jayapura. Buletin Penelitian Kesehatan, 46(2), 87-96

Aptriani, R., Fridayanti., & Barus, A. (2014). Gambaran Jumlah Cd4 Pada Pasien Hiv/Aids Di Klinik Vct Rsud Arifin Achmad Provinsi Riau Periode Januari-Desember 2013. Jom FK, 1, 1-12

Bhatti, A. B., Usman, M., & Venkataramana, K. (2015). Current Scenario of HIV/AID, Treatment Option, and Major Challenges with Compliance to Antiretroviral Therapy. Cureus, 8(3), 515.

Boniphace, I., Minzi, O., Rumisha S. F., & Mugus F., & Tanner M. (2011). HIV/AIDS Clinical Manifestations and the Implication for Patient Clinical Staging in Resource Limited Settings in Tanzania. The Open AIDS Journal, 5(4), 9-16.

Chalker, J. C., Anddualem, T., Gitau, L. N., Ntaganira, J., Obua, C., Tadeg, H., Waako, P., Degnan, D. F. (2010). Measuring adherence to antiretroviral treatment in resource-poor settings: The feasibility of collecting routine data for key indicators. BMC Health Services Research, 10(1), 34-37.

Fajar, E. P. P. (2013). Hubungan Antara Stadium Klinis, Viral Load Dan Jumlah CD4 Pada Pasien Human Immunodeficiency Virus (HIV) / Acquired Immuno Deficiency Syndrome (AIDS) Di RSUP Dr. Kariadi Semarang. Jurnal Media Medika Muda, 3(5), 1-12

Fevrier, M., Dorgham, K., & Rebollo, A. (2017). CD4+ T Cell Depletion in Human Immunodeficiency Virus (HIV) Infection: Role of Apoptosis. Jurnal Viruses, 3(2), 586-612

Hutapea, H. M. L., Mirino, Y., Widiyanti, M., Fitriana, E., Maladan, Y., & Oktavian, A. (2017). Penurunan CD4 Pada ODHA Setelah Terapi ARV Lebih Dari 39 Bulan. The Indonesia Journal of Public Health, 13(3).

Keputusan Menteri Kesehatan Republik Indonesia, (2011). Tentang Rumah Sakit Rujukan Bagi Orang Dengan HIV dan AIDS No. 782 Tahun 2011. Jakarta: Menteri Kesehatan.

Kurniawan, F., Djauzi, S., Yunihastuti, E., & Nugroho, P. (2017). Faktor Prediktor Kegagalan Virologis Pada Pasien HIV Yang Mendapatkan Terpai ARV Lini Pertama Dengan Kepatuhan Berobat Baik. Jurnal Penyakt Dalam Indonesia, 4(1), 29–34

Levine, D., Madsen, A., Wright, E., Barar R. E, Santelli J, & Bull S. (2011). Formative research on MySpace: online methods to engage hard-to-reach populations. Journal of health communication, 16(4), 448–54.

Manuaba, I. A. K. W., & Yasa, I. W. P. S. (2017). Tingkat Kepatuhan Mengkonsumsi Obat Antiretroviral Dengan Jumlah CD4 Pada Pssien HIV/AIDS Di Klinik VCT RSUP Sanglah Dalam Periode September-November 2014. E-Jurnal Medika, 6(1), 2303-1395

Menteri Kesehatan, (2014). Peraturan Menteri Kesehatan Republik Indonesia nomor 87 Tahun 2014 tentang Pedoman Pengobatan Antiretroviral. Jakarta: Menteri Kesehatan

Purnama, S. (2010). Karakteristik penderita HIV/AIDS di Puskesmas Tanjung Morawa Agustus 2006 – Mei 2010. Medan. Tesis Fakultas Kesehatan Masyarakat Universitas Sumatra Utara.

Pettifor, A., Linda, G. B., Sybil, H., Molly, R., & Seana, B. (2013). Preventing HIV among Young People: research priorities for the future. J Acquir Immune Def Syndr, 2, 155-S160.

Thigpen, M. C., Kebabetswe, P. M., & Paxton, L .A. (2012). Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med, 367(5), 423–34.

Valdivia, A., Ly, J., Gonzalez, L., Hussain, P., Saing, T., Islamoglu, H., Pearce, D., Ochoa, C., & Venketaraman, V. (2017). Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts. Aids Research and Human Retroviruses, 33(9), 905-918

World Health Organization, (2016). Consolidated guideline on the use of antiretroviral drugs for treating and preventing HIV infection 2nd ed. Geneva: World Health Organization, 91-154.

Yasin, N. M., Maranty, H., & Ningsih, W. R. (2011). Analisis respon terapi antiretroviral pada pasien HIV/AIDS. Majalah Farmasi Indonesia, 22(3), 212-222

Yogani, I., Karyadi, T. H., & Koesnoe, S. (2015). Faktor-faktor yang Berhubungan dengan Kenaikan CD4 pada Pasien HIV yang Mendapat Highly Active Antiretroviral Therapy dalam 6 bulan Pertama. Jurnal Penyakit Dalam Indonesia. 2(4), 217-222

Yuliandra, Y., Nosa, U. S., Raveinal., & Almasdy, D. (2017). Terapi Antiretroviral pada Pasien HIV/AIDS di RSUP. Dr. M. Djamil Padang: Kajian Sosiodemografi dan Evaluasi Obat. Jurnal Sains Farmasi & Klinis, 4(1), 1-8.

Zipursky, A. R., Gogolishvili, D., Rueda, S., Brunetta, J., Carvalhal, A., McCombe, J. A., & Rourke, S. B. (2013). Evoluation of brief screening tools for neurocognitive imparment in HIV/AIDS. AIDS, 27(15), 2385-2401


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