Comparative study of Aloe vera extract on lipid profile of diabetic rat type 2

  • W Christijanti Department of Biology, Faculty of Mathematic and Natural Science Semarang State University
  • L Suromo Department of Clinical Patology, Faculty of Medicine Diponegoro University Semarang
  • A Z Juniarto Department of Biology, Faculty of Medicine Diponegoro University Semarang


Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. Metabolic disorders in DM are mainly carbohydrate accompanied by fat disorder and protein metabolism. Aloe vera is known as one of the plants for the treatment of various diseases. The aim of this study is to compare the extract of Aloe vera peel and gel to cholesterol, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) on diabetic rat type 2. This study is an experimental study with the sample of 18 diabetic male rats induced by the combination of 65 mg/kg bw of streptozotocin and 230 mg/kg bw of nicotinamide acid. Rats were divided into three groups receiving 0 mg (K), 200 mg of peel extract (P1) and 200 mg/kg of gel extract (P2) for 28 days, feed and water ad libitum. At the end of the study, blood was taken from the orbital veins for measuring cholesterol, triglycerides, LDL and HDL. Data were analyzed by one-way ANOVA at 95% of confidence level and continued by Least Significant Differential (LSD). The result showed that there was a significant difference (P <0.05) between control group, P1 and P2 for cholesterol, triglycerides, LDL and HDL. It could be concluded that Aloe vera peel extract lowers cholesterol, triglycerides and LDL levels, and increases HDL levels better than Aloe vera gel extract.