Creative thinking skill plays important roles in developing student’s creativity in solving problems. This study aims at investigating the influence of project-based learning model in improving students’ creative thinking on colloid subject. This study used experimental one group (pretest-posttest) design. 38 students were involved in this study as the samples. According to the analysis results, the N-gain score of the students’ creative thinking skill was 0.72 (high). The analysis showed that project-based learning model gave significant improvement, and the students showed very good response to project-based learning model. Therefore, the model is recommended to be applied in schools.