Mortality of the Pregnant Women with COVID-19 at Referral Hospitals in Central Java, Indonesia

Sutopo Patria Jati(1), Cipta Pramana(2), Bambang Wibowo(3), Hery Sudjagat(4), Murni Murni(5),

(1) Faculty of Public Health, Diponegoro University, Semarang, Indonesia
(2) Institue of Health Science Guna Bangsa Yogyakarta Department of Obstetrics and Gynecology KRMT Wongsonegoro Hospital Semarang, Indonesia
(3) Department of Obstetrics and Gynecology Faculty of Medicine, Diponegoro University Semarang, Indonesia Department of Obstetrics and Gynecology Dr. Kariyadi Hospital Semarang, Indonesia
(4) Department of Internal Medicine, Faculty of Medicine, Diponegoro University Semarang, Indonesia
(5) Temanggung District Health Office, Indonesia


Pregnant women have a high potential for infectious infections including Covid-19. This study focused on analysing the characteristics and outcomes of 95 maternal deaths that were caused by COVID-19. This observational-retrospective study descriptively analysed 95 maternal deaths due to COVID-19. The study was conducted in June – July 2021 at the COVID-19 Referral hospitals in Central Java Province. The study found that the majority of these deaths occurred in women between the ages of 20 to 35, with 74% falling in this age range. Furthermore, the study found that 63.2% of the patients required treatment for more than 48 hours. The study also noted that almost all of the women who died (98.9%) had not been vaccinated against COVID-19. Of the patients who received treatment, 73.7% received standard therapy. Additionally, 55.8% of the patients had a moderate condition when admitted to the hospital. More than half of the patients (52.6%) died in the intensive care unit (ICU). Furthermore, 63.2% of the patients arrived at the hospital alone. This data may suggest that some of these women were not receiving adequate support or medical care before their hospitalisation.


Pregnant women, COVID-19, maternal mortality in the hospitals, status vaccination of COVID-19, COVID-19 referral hospital.


Akbar, M. I. A., Gumilar, K. E., Andriya, R., Wardhana, M. P., Mulawardhana, P., Anas, J. Y., Ernawati, Laksana, M. A. C., & Dekker, G. (2022). Clinical manifestations and pregnancy outcomes of COVID-19 in indonesian referral hospital in central pandemic area. Obstetrics & Gynecology Science, 65(1), 29–36.

Allotey, J., Stallings, E., Bonet, M., Yap, M., Chatterjee, S., Kew, T., Debenham, L., Llavall, A. C., Dixit, A., Zhou, D., Balaji, R., Lee, S. I., Qiu, X., Yuan, M., Coomar, D., van Wely, M., van Leeuwen, E., Kostova, E., Kunst, H., … Thangaratinam, S. (2021). Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: Living systematic review and meta-analysis. Obstetric Anesthesia Digest, 41(2), 81–82.

Anggraeni, M. D., Setiyani, R., Triyanto, E., Iskandar, A., Nani, D., & Fatoni, A. (2023). Exploring the antenatal care challenges faced during the COVID-19 pandemic in rural areas of Indonesia: A qualitative study. BMC Pregnancy and Childbirth, 23(1).

Central Java Covid-19 Task Force. (2021). Laporan Update Penanganan Covid di Jawa Tengah Minggu ke 26 tahun 2021/Update Report Covid handling 26th Week 2021 . (not published).

Chew, S. Y., Lee, Y. S., Ghimiray, D., Tan, C. K., & Chua, G. S. (2020). Characteristics and outcomes of COVID-19 patients with respiratory failure admitted to a “pandemic ready” intensive care unit – lessons from singapore. Annals of the Academy of Medicine, Singapore, 49(7), 434–448.

Dashraath, P., Wong, J. L. J., Lim, M. X. K., Lim, L. M., Li, S., Biswas, A., Choolani, M., Mattar, C., & Su, L. L. (2021). Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Obstetric Anesthesia Digest, 41(1), 7–7.

de Freitas Paganoti, C., Alkmin da Costa, R., Papageorghiou, A. T., da Silva Costa, F., Quintana, S. M., Graziela de Godoi, L., Adriana Jiménez Monroy, N., Sacramento Rodrigues, A., & Pulcineli Vieira Francisco, R. (2022). COVID-19 vaccines confer protection in hospitalized pregnant and postpartum women with severe COVID-19: A retrospective cohort study. Vaccines, 10(5), 749.

Helmyati, S., Dipo, D., Rekso Adiwibowo, I., Wigati, M., Larene Safika, E., Hafizh Hariawan, M., Destiwi, M., Prajanta, Y., Penggalih, M., Sudargo, T., Herawati, D., Marthias, T., Masrul, M., & Trisnantoro, L. (2022). Monitoring continuity of maternal and child health services, Indonesia. Bulletin of the World Health Organization, 100(02), 144–154.

Jamieson, D. J., & Rasmussen, S. A. (2022). An update on COVID-19 and pregnancy. American Journal of Obstetrics and Gynecology, 226(2), 177–186.

Mahajan, N. N., Pophalkar, M., Patil, S., Yewale, B., Chaaithanya, I. K., Mahale, S. D., & Gajbhiye, R. K. (2021). Pregnancy outcomes and maternal complications during the second wave of coronavirus disease 2019 (COVID-19) in india. Obstetrics & Gynecology, 138(4), 660–662.

Mart, M. F., Sendagire, C., Ely, E. W., Riviello, E. D., & Twagirumugabe, T. (2022). Oxygen as an essential medicine. Critical Care Clinics, 38(4), 795–808.

Mirbeyk, M., Saghazadeh, A., & Rezaei, N. (2021). A systematic review of pregnant women with COVID-19 and their neonates. Archives of Gynecology and Obstetrics, 304(304).

Nana, M., Hodson, K., Lucas, N., Camporota, L., Knight, M., & Nelson-Piercy, C. (2022). Diagnosis and management of covid-19 in pregnancy. British Medical Journal (BMJ), 377(377), e069739.

Ospina-Tascón, G. A., Martínez, D., & Gempeler, A. (2022). High-Flow oxygen vs conventional oxygen and invasive mechanical ventilation and clinical recovery in patients with severe covid-19—reply. JAMA, 327(11), 1092.

Phoswa, W. N., & Khaliq, O. P. (2020). Is pregnancy a risk factor of COVID-19? European Journal of Obstetrics & Gynecology and Reproductive Biology, 252, 605–609.

Pramana, C., Herawati, S., Santi, N., Rosreri, Maryani, L. P. E. S., & Dachliana, O. R. (2020). The first case of COVID-19 in semarang, indonesia: A case report. International Journal of Pharmaceutical Research, 12(02).

Purwono, A., Agustin, H., Lisnawati, Y., & Faisal, H. K. P. (2023). Respiratory perspective of COVID-19 in pregnancy. The Journal of Infection in Developing Countries, 17(01), 23–36.

Schwartz, D. A. (2020). An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of sars-cov-2: Maternal coronavirus infections and pregnancy outcomes. Archives of Pathology & Laboratory Medicine, 144(7), 799–805.

Sharma, A., Ahmad Farouk, I., & Lal, S. K. (2021). COVID-19: A review on the novel coronavirus disease evolution, transmission, detection, control and prevention. Viruses, 13(2), 202.

Sujarwoto, S., & Maharani, A. (2022). Sociodemographic characteristics and health access associated with COVID-19 infection and death: A cross-sectional study in Malang District, Indonesia. BMJ Open, 12(5), e052042.

Sumarni, N., Dewiyanti, L., Kusmanto, M. H., & Pramana, C. (2020). A case of 2019 novel coronavirus infection in a preterm infant with severe respiratory failure. International Journal of Pharmaceutical Research, 12(04).

Surendra, H., Elyazar, I. R., Djaafara, B. A., Ekawati, L. L., Saraswati, K., Adrian, V., Widyastuti, Oktavia, D., Salama, N., Lina, R. N., Andrianto, A., Lestari, K. D., Burhan, E., Shankar, A. H., Thwaites, G., Baird, J. K., & Hamers, R. L. (2021). Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study. The Lancet Regional Health - Western Pacific, 9, 100108.

Taccone, F. S., Van Goethem, N., De Pauw, R., Wittebole, X., Blot, K., Van Oyen, H., Lernout, T., Montourcy, M., Meyfroidt, G., & Van Beckhoven, D. (2021). The role of organizational characteristics on the outcome of COVID-19 patients admitted to the ICU in Belgium. The Lancet Regional Health - Europe, 2(2), 100019.

Utami, A., Margawati, A., Pramono, D., Nugraheni, A., & Pramudo, S. (2022). Determinant factors of COVID-19 vaccine hesitancy among adult and elderly population in central java, indonesia. Patient Preference and Adherence, Volume 16(16), 1559–1570.

van Empel, G., Mulyanto, J., & Wiratama, B. S. (2020). Undertesting of COVID-19 in Indonesia: What has gone wrong? Journal of Global Health, 10(2).

Villar, J., Ariff, S., Gunier, R. B., Thiruvengadam, R., Rauch, S., Kholin, A., Roggero, P., Prefumo, F., do Vale, M. S., Cardona-Perez, J. A., Maiz, N., Cetin, I., Savasi, V., Deruelle, P., Easter, S. R., Sichitiu, J., Soto Conti, C. P., Ernawati, E., Mhatre, M., … Papageorghiou, A. T. (2021). Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection. JAMA Pediatrics, 175(8), 817.

Wei, S. Q., Bilodeau-Bertrand, M., Liu, S., & Auger, N. (2021). The impact of COVID-19 on pregnancy outcomes: A systematic review and meta-analysis. Canadian Medical Association Journal, 193(16), E540–E548.

Widiawaty, M. A., Lam, K. C., Dede, M., & Asnawi, N. H. (2022). Spatial differentiation and determinants of COVID-19 in Indonesia. BMC Public Health, 22(1).

Yarnell, C. J., & Sklar, M. C. (2022). Noninvasive respiratory strategies and intubation or mortality among patients with acute hypoxemic respiratory failure due to COVID-19. JAMA, 327(20), 2023.

Yu, N., Li, W., Kang, Q., Xiong, Z., Wang, S., Lin, X., Liu, Y., Xiao, J., Liu, H., Deng, D., Chen, S., Zeng, W., Feng, L., & Wu, J. (2020). Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A retrospective, single-centre, descriptive study. The Lancet Infectious Diseases, 20(5), 559–564.


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