Adherence to Taking ARV Drugs in Adolescents with HIV/AIDS

Nuraidah Nuraidah(1), Dessie Wanda(2),

DOI: https://doi.org/10.15294/kemas.v17i3.23220


(1) Universitas Indonesia
(2) 

Abstract

Adherence on taking ARV drugs in adolescents is the main issue in the success of ARV treatment. ARV treatment is related to improving the quality of life in adolescents infected with HIV. Aim: To summarize the factors improving adherence on HIV medication using ARV drugs in adolescents. Method: This article is a review of journal articles related to adherence on taking ARV drugs. Article reviewed were the articles on the past five years, 2015-2019, with a search strategy involving the articles from the following database including Science Direct, Scopus and ProQuest databases. Results: 12 articles related to adherence on ARV medication in adolescents. Conclusion: adherence is a significant aspect that must be maintained in order to overcome the impact of non-compliance on ARV medication as it can affect the quality of life of adolescents with HIV / AIDS.

Keywords

Adherence, adolescent, Antiretroviral, HIV/AIDS

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References

Ammon, N., Mason, S., & Corkery, J.M., 2018. Factors Impacting Antiretroviral Therapy Adherence among Human Immunodeficiency Virus–positive Adolescents in Sub-Saharan Africa: A Systematic Review. Public Health, 157(1), pp.20-31.

Anima-Korang, A., Gere, B.O., & Salimi, N., 2018. Stigma and Discrimination: Coping Strategies for Persons Living with HIV/AIDS in Rural America. IAFOR Journal of Psychology & the Behavioral Sciences, 4(1), pp.1-13.

Ankrah, D.N., Koster, E.S., Mantel-Teeuwisse, A.K., Arhinful, D.K., Agyepong, I.A., & Lartey, M., 2016. Facilitators and Barriers to Antiretroviral Therapy Adherence Among Adolescents in Ghana. Patient Preference and Adherence, 10(1), pp.329-337.

Ashaba, S., Cooper-Vince, C.E., Vořechovská, D., Rukundo, G.Z., Maling, S., Akena, D., & Tsai, A.C., 2019. Community beliefs, HIV Stigma, and Depression Among Adolescents Living with HIV in Rural Uganda. African Journal of AIDS Research, 18(3), pp.169-180.

Beima-Sofie, K.M., Brandt, L., Hamunime, N., Shepard, M., Uusiku, J., John-Stewart, G.C., & O’Malley, G., 2017. Pediatric HIV Disclosure Intervention Improves Knowledge and Clinical Outcomes in HIV-infected Children in Namibia. Journal of Acquired Immune Deficiency Syndromes, 75(1), pp.18-26.

Bermudez, L.G., Jennings, L., Ssewamala, F.M., Nabunya, P., Mellins, C., & McKay, M., 2016. Equity in Adherence to Antiretroviral Therapy Among Economically Vulnerable Adolescents Living with HIV in Uganda. AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 28(52), pp.83-91.

Chhim, K., Mburu, G., Tuot, S., Sopha, R., Khol, V., Chhoun, P., & Yi, S., 2018. Factors Associated with Viral Non-Suppression Among Adolescents Living with HIV in Cambodia: A Cross-sectional Study. AIDS Research and Therapy, 15(1), pp.1-10.

Cluver, L.D., Hodes, R.J., Toska, E., Kidia, K.K., Orkin, F.M., Sherrf, L., & Meincka, F., 2015. HIV is Like A Tsotsi. ARVs are Your Guns’: Associations between HIV-disclosure and Adherence to Antiretroviral Treatment Among Adolescents in South Africa. Aids, 29(1), pp.S57-S65.

Dahoklory, B.M., Romeo, P., & Takaeb, A.E., 2019. The Relationship between Family Support for PLWHA and Adherence to Taking Antiretroviral Drugs at the VCT Clinic-Sobat Kupang. Timorese Journal of Public Health, 1(2), pp.70-78.

Damulira, C., Mukasa, M.N., Byansi, W., Nabunya, P., Kivumbi, A., Namatovu, P., Namuwonge, F., Dvalishvili, D., Bahar, O.S., & Ssewamala, F.M., 2019. Examining the Relationship of Social Support and Family Cohesion on ART Adherence Among HIV-positive Adolescents in Southern Uganda: Baseline Findings. Vulnerable Children and Youth Studies, 14(2), pp.181-190.

Denison, J.A., Banda, H., Dennis, A.C., Packer, C., Nyambe, N., Stalter, R.M., Mwansa, J.K., Katayamoyo, P., & McCarraher, D.R., 2015. The Sky is the Limit: Adhering to Antiretroviral Therapy and HIV Self-management from the Perspectives of Adolescents Living with HIV and Their Adult Caregivers. Journal of the International AIDS Society, 18(1), pp.1-7.

DeSilva, M.B., Penwill, N., Sabin, L., Gifford, A.L., Li, Z., Fujie, Z., Weiwei, M., Yongzhen, L., Hongyan, L., Xuemei, Z., Barnoon, Y., Gill, C.J., & Bonawitz, R., 2018. We Don’t Dare to Tell Her … We Don’t Know Where to Begin: Disclosure Experiences and Challenges among Adolescents Living with HIV and Their Caregivers in China. International Journal of Pediatrics and Adolescent Medicine, 5(1), pp.5-12.

Elyanu, P., Nabukeera-Barungi, N., Asire, B., Katureebe, C., Lukabwe, I., Namusoke, E., Musinguzi, J., Atuyambe, L., & Tumwesigye, N., 2015. Adherence to Antiretroviral Therapy and Retention in Care for Adolescents Living with HIV from 10 Districts in Uganda. BMC Infectious Diseases, 15(1), pp.1-11.

Fadila, R.N., & Riono, P., 2014. Effect of Regimen on Non-adherence to Tuberculosis Treatment. National Journal of Public Health, 9(2), pp.107-112.

Firdu, N., Enquselassie, F., & Jerene, D. (2017). HIV-infected adolescents have low adherence to antiretroviral therapy: A cross-sectional study in Addis Ababa, Ethiopia. Pan African Medical Journal, 27(80), 1-11.

Galea, J.T., Wong, M., Muñoz, M., Valle, E., Leon, S.R., Perez, D.D., Kolevic, L., & Franke, M., 2018. Barriers and Facilitators to Antiretroviral Therapy Adherence Among Peruvian Adolescents Living with HIV: A Qualitative Study. PLoS ONE, 13(2), pp.1-19.

Gebremedhin, M., Gebrehawerya, T., Tesfaye, G., Gebretsadik, G., & Kebede, L., 2017. Stigma and Discrimination Towards HIV Positive People Among in-school Adolescents, in Babile Town, Eastern Ethiopia: A Cross Sectional Study. Journal of HIV and AIDS, 3(3), pp.1-5.

Graves, J.C., Elyanu, P., Schellack, C.J., Asire, B., Prust, M.L., Prescott, M.R., Mirembe, E., Lukabwe, I., Mirembe, B., Musinguzi, J., & Moberley, S.A., 2018. Impact of A Family Clinic Day Intervention on Paediatric and Adolescent Appointment Adherence and Retention in Antiretroviral Therapy: A Cluster Randomized Controlled Trial in Uganda. PLoS ONE, 13(3), pp.1-19.

Heestermans, T., Browne, J.L., Aitken, S.C., Vervoort, S.C., & Klipstein-Grobusch, K., 2016. Determinants of Adherence to Antiretroviral Therapy among HIV-positive Adults in sub-Saharan Africa: A Systematic Review. BMJ Global Health, 1(4), pp.1-14.

Holtzman, C.W., Brady, K.A., & Yehia, B.R., 2015. Retention in Care and Medication Adherence: Current Challenges to Antiretroviral Therapy Success. HHS Public Access, 1(4), pp.1-18.

Hornschuh, S., Dietrich, J.J., Tshabalala, C., & Laher, F., 2017. Antiretroviral Treatment Adherence: Knowledge and Experiences Among Adolescents and Young Adults in Soweto, South Africa. AIDS Research and Treatment, 2017(1), pp.1-9.

Hudelson, C., & Cluver, L., 2015. Factors Associated with Adherence to Antiretroviral Therapy Among Adolescents Living with HIV / AIDS in Low- and Middle-income Countries : A Systematic Review. AIDS Care, 27(7), pp.805-816.

Isni, K., 2016. Family Support, Support from Health Workers, and Behavior of HIV Mothers in Preventing HIV/AIDS Transmission to Babies. Journal of Public Health, 11(2), pp.96-104.

James, S.R., Nelson, K.A., & Ashwill, J.W., 2013. Nursing Care of Children: Principles & Practice. St. Louis: Saunders, Elsevier.

Kabore, L., Muntner, P., Chamot, E., Zinski, A., Burkholder, G., & Mugavero, M.J., 2015. Self-report Measures in the Assessment of Antiretroviral Medication Adherence: Comparison with Medication Possession Ratio and HIV Viral Load. Journal of the International Association of Providers of AIDS Care, 14(2), pp.156-162.

Kariuki, T.W., Some, E.S., & Kimanthi, G., 2016. Determinants of Antiretroviral Treatment Adherence among HIV/ AIDS Infected Adolescents in Thika Level 5 Hospital. International Academic Journals, 1(1), pp.1-10.

Kementrian Kesehatan RI., 2014. Guidelines for the Application of HIV Therapy in Children. Jakarta: Kemenkes RI.

Kementrian Kesehatan RI., 2018. National Standard Guidelines for Adolescent Care Health Services (PKPR). Jakarta: Kementrian Kesehatan RI.

Kementrian Kesehatan RI., 2019. Report on the Progress of HIV AIDS and PIMS in the Second Quarter of 2019. Jakarta: Ditjen P2P.

Kim, S.H., Gerver, S.M., Fidler, S., & Ward, H., 2014. Adherence to Antiretroviral Therapy in Adolescents Living with HIV: Systematic Review and Meta-analysis. AIDS, 28(13), pp.1945-1956.

Kimera, E., Vindevogel, S., Kintu, M.J., Rubaihayo, J., De-Maeyer, J., Reynaert, D., Engelen, A.-M., Nuwaha, F., & Bilsen, J., 2020. Experiences and Perceptions of Youth Living with HIV in Western Uganda on School Attendance: Barriers and Facilitators. BMC Public Health, 20(1), pp.1-13.

Leon, C., Koosed, T., Philibert, B., Raposo, C., & Benzaken, A.S., 2019. HIV/AIDS Health Services in Manaus, Brazil: Patient Perception of Quality and Its Influence on Adherence to Antiretroviral Treatmen. BMC Health Services Research, 19(1), pp.1-11.

Lypen, K.D., Lockwood, N., Shalabi, F., Harper, G.W., & Ngugi, E., 2015. When We are Together I Feel at Home. Types and Sources of Social Support Among Youth Newly Diagnosed with HIV in Kenya: Implications for Intervention. African Journal of AIDS Research, 14(3), pp.275-284.

Maccarthy, S., Saya, U., Samba, C., Birungi, J., Okoboi, S., & Linnemayr, S., 2018. How am I Going to Live ?: Exploring Barriers to ART Adherence among Adolescents and Young Adults Living with HIV in Uganda. BMC Public Health, 18(1158), pp.1-11.

Mark, D., Armstrong, A., Andrade, C., Penazzato, M., Hatane, L., Taing, L., Runciman, T., & Ferguson, J., 2017. HIV Treatment and Care Services for Adolescents: A Situational Analysis of 218 Facilities in 23 Sub-Saharan African Countries. Journal of the International AIDS Society, 20(3), pp.25-33.

Medin, G., García-Navarro, C., Navarro, G.M., Ramos, A.J.T., Mellado, M J., Jimenez, S., 2015. Disease Disclosure, Treatment Adherence, and Behavioural Profile in a Cohort of Vertically Acquired HIV-infected Adolescents. NeuroCoRISpeS study. AIDS Care, 28(1), pp.1-7.

Montalto, G.J., Sawe, F.K., Miruka, A., Maswai, J., Kiptoo, I., Aoko, A., Oreyo, C., Obiero, E., Korir, S., Bii, S.K., Song, K.X., & Kunz, A.N., 2017. Diagnosis Disclosure to Adolescents Living with HIV in Rural Kenya Improves Antiretroviral Therapy Adherence and Immunologic Outcomes: A Retrospective Cohort Study. PLoS ONE, 12(10), pp.1-11.

Nalugya, R., Russell, S., Zalwango, F., & Seeley, J., 2018. The Role of Children in Their HIV-positive Parents’ Management of Antiretroviral Therapy in Uganda. African Journal of AIDS Research, 17(1), pp.37-46.

Okawa, S., Mwanza, K.S., Mwiya, M., Kikuchi, K., Jimba, M., Kankasa, C., & Ishikawa, N., 2018. Psychological Well-being and Adherence to Antiretroviral Therapy among Adolescents Living with HIV in Zambia. AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 30(5), pp.634-642.

Ramaiya, M.K., Sullivan, K.A., O’Donnell, K., Cunningham, C.K., Shayo, A.M., Mmbaga, B.T., & Dow, D.E., 2016. A Qualitative Exploration of the Mental Health and Psychosocial Contexts of HIV-positive Adolescents in Tanzania. PLoS ONE, 11(11), pp.1-13.

Shaluhiyah, Z., Suryoputro, A., & Setyawati, A., 2017. The Need of Information Services on Reproductive Health, STIs And HIV in Middle Adolescent. Journal of Public Health, 12(2), pp.96-105.

Sosodoro, O., Ahmad, R.A., Prabandari, Y.S., & Hakimi, M., 2017. Internal Stigma of An Hiv Infected Housewife: A Phenomenological Study. Journal of Public Health, 13(2), pp.158-168.

Ssewamala, F. M., Byansi, W., Bahar, O.S., Nabunya, P., Neilands, T.B., Mellins, C., McKay, M., Namuwonge, F., Mukasa, M., Makumbi, F.E., & Nakigozi., 2019. Suubi+Adherence Study Protocol: A Family Economic Empowerment Intervention Addressing HIV Treatment Adherence for Perinatally Infected Adolescents. Contemporary Clinical Trials Communications, 16(100463), pp.2451-8654.

Sugiharti, H.R.S., Lestary, H., Mujiati., & Susyanti, A.L., 2019. Stigma and Discrimination Against Children with HIV AIDS (ADHA) in Ten Districts/Cities in Indonesia. Journal of Reproductive Health, 10(2), pp.153-161.

Umar, E., Levy, J.A., Donenberg, G., Mackesy-Amiti, M.E., Pujasari, H., & Bailey, R.C., 2019. The Influence of Self-efficacy on the Relationship Between Depression and HIV-Related stigma with ART Adherence among the Youth in Malawi. Jurnal Keperawatan Indonesia, 22(2), pp.147–160.

UNAIDS., 2017. UNAIDS Data 2017. Switzerland: UNAIDS.

UNAIDS. 2018. UNAIDS Data 2018. Switzerland: UNAIDS.

Vyas, K.J., Limneos, J., Qin, H., & Mathews, W.C., 2014. Assessing Baseline Religious Practices and Beliefs to Predict Adherence to Highly Active Antiretroviral Therapy among HIV-infected Persons. AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 26(8), pp.983-987.

Woollett, N., Cluver, L., M.Hatcher, A., & Brahmbhatt, H., 2016. To be HIV Positive is not the End of the World: Resilience among Perinatally Infected HIV Positive Adolescents in Johannesburg. Children and Youth Services Review, 70(C), pp.269-275.

Xu, L., Munir, K., Kanabkaew, C., & Le-Coeur, S., 2017. Factors Influencing Antiretroviral Treatment Suboptimal Adherence Among Perinatally HIV Infected Adolescents in Thailand. PLoS ONE, 12(2), pp.1-18.

Yi, S., Tuot, S., Pal, K., Khol, V., Sok, S., Chhoun, P., Ferguson, L., & Mburu, G., 2018. Characteristics of Adolescents Living with HIV Receiving Care and Treatment Services in Antiretroviral Therapy Clinics in Cambodia: Descriptive Findings from A Cross-sectional Study. BMC Health Services Research, 18(1), pp.1-13.

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