Survival Analysis of Tuberculosis Patients Based on Diabetes Mellitus Status in West Sumatra

Mega Utami Basra(1), Defriman Djafri(2), Zurayya Fadila(3),


(1) Universitas Andalas
(2) Universitas Andalas
(3) Universitas Andalas

Abstract

Tuberculosis (TB) is still one of the main problems in tropical countries, especially in Indonesia. The existence of conditions that cause decreased immune systems, such as Diabetes Mellitus (DM), can lead to an increased risk of death in people with Tuberculosis. This study aimed to analyze the survival of Tuberculosis patients with a history of DM in West Sumatra Province. This research was conducted from April to October 2022. It is a retrospective cohort study with all TB patients recorded in the TB03 SO data register in West Sumatra Province in 2021 (N=8,299). The samples were all candidates who met the research criteria in the data (n=1,125 TB patients). Data analysis was performed using survival analysis. The results showed that 177 TB patients (15.73%) had a history of DM, and 948 (84.27%) did not. The cumulative probability of survival for TB patients based on non-DM cases on day 150 is 0.95. In contrast, the cumulative probability of survival for patients with a history of DM is lower, namely 0.90. The group of TB patients who suffered from DM, male and more than 45 years old, experienced a more significant decrease in survival.

 

Keywords

Age; DM; Mortality; Sex; TB

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References

Alkabab, Y., Al-Abdely, H., & Heysell, S. (2015). Diabetes-Related Tuberculosis in The Middle East: An Urgent Need for Regional Research. Int J Infect Dis, 40, 64–70. https://doi.org/DOI:10.1016/j.ijid.2015.09.010

Baker, M. A., Harries, A. D., Jeon, C. Y., Hart, J. E., Kapur, A., Lönnroth, K., Ottmani, S. E., Goonesekera, S. D., & Murray, M. B. (2011). The impact of diabetes on tuberculosis treatment outcomes: A systematic review. BMC Medicine, 9. https://doi.org/10.1186/1741-7015-9-81

Berbudi, A., Rahmadika, N., Tjahjadi, A. I., & Ruslami, R. (2020). Type 2 Diabetes and its Impact on the Immune System. Current Diabetes Reviews, 16(5), 442. https://doi.org/10.2174/1573399815666191024085838

Carter, B. B., Zhang, Y., Zou, H., Zhang, C., Zhang, X., Sheng, R., Qi, Y., Kou, C., & Li, Y. (2021). Survival analysis of patients with tuberculosis and risk factors for multidrug-resistant tuberculosis in Monrovia, Liberia. PLOS ONE, 16(4), e0249474. https://doi.org/10.1371/JOURNAL.PONE.0249474

Dian Saraswati, L. (2014). Prevalens Diabetes Mellitus dan Tuberkulosis Paru. Jurnal Kesehatan Masyarakat, 9(2), 206–2010. https://doi.org/10.15294/kemas.v9i2.2850

dos Santos, D. T., Arroyo, L. H., Alves, Y. M., Alves, L. S., Berra, T. Z., Crispim, J. de A., Alves, J. D., Ramos, D. A. C., Alonso, J. B., de Assis, I. S., Ramos, A. V., Dessunti, E. M., Carvalho Pinto, I., Palha, P. F., Arcêncio, R. A., & Nunes, C. (2021). Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil. Tropical Medicine and Health, 49(1), 1–14. https://doi.org/10.1186/S41182-021-00320-4/TABLES/5

Feng, J. Y., Huang, S. F., Ting, W. Y., Chen, Y. C., Lin, Y. Y., Huang, R. M., Lin, C. H., Hwang, J. J., Lee, J. J., Yu, M. C., Yu, K. W., Lee, Y. C., & Su, W. J. (2012). Gender differences in treatment outcomes of tuberculosis patients in Taiwan: a prospective observational study. Clinical Microbiology and Infection : The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(9). https://doi.org/10.1111/J.1469-0691.2012.03931.X

Geleso, M. G. (2020). Modeling the survival of tuberculosis patients in eastern zone of Tigray regional state. Risk Management and Healthcare Policy, 13, 473–481. https://doi.org/10.2147/RMHP.S251376

Haile, T., Mohammed, K., Assefa, E., & Schumacher, U. (2021). Determinanet of the survival pattern of tuberculosis patients treated under directly observed treatment short course at Pawe Hospital, Ethiopia. Cogent Medicine, 8(1). https://doi.org/10.1080/2331205X.2021.1944477

Hayashi, S., & Chandramohan, D. (2018). Risk of active tuberculosis among people with diabetes mellitus: systematic review and meta-analysis. Tropical Medicine & International Health : TM & IH, 23(10), 1058–1070. https://doi.org/10.1111/TMI.13133

Jiménez-Corona, M. E., García-García, L., DeRiemer, K., Ferreyra-Reyes, L., Bobadilla-Del-Valle, M., Cano-Arellano, B., Canizales-Quintero, S., Martínez-Gamboa, A., Small, P. M., Sifuentes-Osornio, J., & Ponce-De-León, A. (2006). Gender differentials of pulmonary tuberculosis transmission and reactivation in an endemic area. Thorax, 61(4), 348. https://doi.org/10.1136/THX.2005.049452

Kemenkes RI. (2019). Profil Kesehatan Indonesia Tahun 2019. Kementerian Kesehatan Republik Indonesia.

Leal, S., Araújo, G., Nery, J., Santos, Oliveira, M., Barreto, M., & Pereira, S. (2017). Clinical and Epidemiological Aspects of Cases of Tuberculosis Associated with Diabetes in Salvador, Bahia, Brazil. Rev Soc Bras Med Trop, 50(3), 408–412. https://doi.org/doi: 10.1590/0037-8682-0409-2016

Liu, K., Ai, L., Pan, J., Fei, F., Chen, S., Zhang, Y., Wang, W., Wu, Q., Chen, B., Pan, J., & Zhong, J. (2022). Survival Analysis and Associated Factors for Pulmonary Tuberculosis Death: Evidence from the Information System of Tuberculosis Disease and Mortality Surveillance in China. Risk Management and Healthcare Policy, 15, 1167–1178. https://doi.org/10.2147/RMHP.S368593

Lönnroth, K., Roglic, G., & Harries, A. (2014). Improving Tuberculosis Prevention and Care Through Addressing the Global Diabetes Epidemic: from Evidence to Policy and Practice. Lancet Diabetes Endocrinol, 2, 730–739. https://doi.org/DOI:10.1016/S2213-8587(14)70109-3

Moosazadeh, M., Bahrampour, A., Nasehi, M., & Khanjani, N. (2014). Survival and Predictors of Death after Successful Treatment among Smear Positive Tuberculosis: A Cohort Study. International Journal of Preventive Medicine, 5(8), 1005. /pmc/articles/PMC4258661/

Rahmanian, V., Rahmanian, K., Rahmanian, N., Rastgoofard, M., & Mansoorian, E. (2018). Survival rate among tuberculosis patients identified in south of Iran, 2005-2016. Journal of Acute Disease, 7(5), 207. https://doi.org/10.4103/2221-6189.244172

Ratnasari, N. Y., & Handayani, S. (2023). Tuberculosis Research Trends in Indonesian Health Scientific Journals: From Research Design to Data Analysis. Jurnal Kesehatan Masyarakat, 18(4), 483–491. https://doi.org/10.15294/kemas.v18i4.39699

Ruslami, R., Aarnoutse, R., & Alisjahbana, B. (2010). Implications of The Global Increase of Diabetes for Tuberculosis Control and Patient Care. Trop Med Int Health, 15, 1289–1299. https://doi.org/DOI:10.1111/j.1365- 3156.2010.02625.x

Selvaraju, S., Thiruvengadam, K., Watson, B., Thirumalai, N., Malaisamy, M., Vedachalam, C., Swaminathan, S., & Padmapriyadarsini, C. (2021). Long-term Survival of Treated Tuberculosis Patients in Comparison to a General Population In South India: A Matched Cohort Study. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 110, 385–393. https://doi.org/10.1016/J.IJID.2021.07.067

Teketelew, G., Medhin, G., Fenta, T. G., Teketelew, G., Medhin, G., & Fenta, T. G. (2022). Survival and Its Predictors among Tuberculosis Patients on Treatment in Selected Health Centers of Addis Ababa, Ethiopia: A Retrospective Cohort Study. Open Journal of Preventive Medicine, 12(10), 223–238. https://doi.org/10.4236/OJPM.2022.1210017

WHO. (2020). World Health Organization. Global Tuberculosis Report. https://www.who.int/publications/i/item/9789240013131

Xie, Y., Han, J., Yu, W., Wu, J., Li, X., & Chen, H. (2020). Survival Analysis of Risk Factors for Mortality in a Cohort of Patients with Tuberculosis. Canadian Respiratory Journal, 2020. https://doi.org/10.1155/2020/1654653

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