Sleep Quality Affects Humoral Response in Recipients of Two-Dose Sinovac Vaccines

Linawati Hananta(1), Victoria Larasati(2), Surilena Surilena(3),

DOI: https://doi.org/10.15294/kemas.v18i4.41950


(1) School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia
(2) School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia
(3) School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Abstract

To curb the COVID-19 pandemic, the government distributed Sinovac vaccines. Sleep mediates immune function, including post-vaccination antibody response. This study aimed to analyze whether there was a difference in post-vaccination antibody levels in Sinovac vaccine recipients with poor and good sleep quality. This study used analytical observations of recipients of the two-dose Sinovac vaccine in 2021. Primary data included age, sex, the Pittsburgh Sleep Quality Index (PSQI) questionnaire, and post-vaccination IgG-SARS-CoV-2 antibody levels. The PSQI and IgG SARS-CoV-2 antibody levels were measured a month after the second vaccination. Participants with non-reactive antibody levels before the first vaccination were included, and participants with incomplete data were excluded. The Mann-Whitney test was used to look for associations between sleep quality and post-vaccination IgG SARS-CoV-2 levels. Univariate analysis showed that of 54 participants, 37 (68.5%) were male, and 28 (51.9%) had poor sleep quality. 15 participants (27.78%) were in the 36-45 age group, and median antibody levels in participants who received the second Sinovac Vaccine was 223.5 (199.01) units/mL. Post-vaccination IgG SARS-CoV-2 antibody levels were significantly associated with sleep quality (p=0.036).

Keywords

antibody; SARS-CoV-2; COVID-19 vaccine; inactivated vaccine; sleep quality

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