Risk Factors of Autism Spectrum Disorder (ASD)

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Andri Dwi Hernawan
Aisyah Diningrum
Sri Nugroho Jati
M. Nasip

Abstract

Abstract


There were 112,000 ASD sufferers in Indonesia in 2012 and in 2015 it was estimated that there were 1 per 250 children or 134,000 sufferers. The proportion of ASD was 62.8% and in 2016 it was 1.28 out of 1000 children in 2015. This study aimed to determine the risk factors for the incidence of ASD in Pontianak City. The research method was analytic observational with a control case study design. The sample was 70 people (35 cases and 35 controls) taken by purposive sampling technique. Data analysis used Chi-Square test (α = 0,05). The results showed that the factors associated with the incidence of ASD were father's age (p = 0.03; OR = 4.00; CI = 1.250-12.804), stress history during pregnancy (p = 0.04; OR = 3.18; CI = 1.13-8.93) and insufficient months of birth (p = 0.036; OR = 4.88; CI = 1.22-19.4), while age of mother during pregnancy, passive smoker, antenatal hemorrhage and pregnancy interval were not associated with the incidence of ASD (p> 0.05). The conclusion of this study is father's age, the presence of a history of stress during pregnancy and insufficient months of birth associated with the incidence of ASD.


Keywords: Father’s age, Stress History, Autism Spectrum Disorder


 


Abstrak


Autism Spectrum Disorder (ASD) dikenal sebagai triad of impairments yaitu adanya gangguan perkembangan pada aspek komunikasi, adanya perilaku yang diulang-ulang dan gangguan dalam berinteraksi dengan lingkungan. Pada tahun 2012 dilaporkan sebanyak 112.000 penderita ASD di Indonesia, tahun 2015 diperkirakan terdapat 1 per 250 anak atau 134.000 penderita. Data dari UPTD Autis Center Kota Pontianak tahun 2015 proporsi ASD sebesar 62,8% dan pada tahun 2016 sebesar 1,28 dari 1000 anak. Penelitian ini bertujuan untuk mengetahui faktor risiko kejadian ASD di Kota Pontianak. Metode penelitian adalah observasional analitik dengan desain studi kasus kontrol.Sampel penelitian berjumlah 70 orang (35 kasus dan 35 kontrol) yang diambil dengan teknik purposive sampling. Analisis data menggunakan uji Chi-Square (α=0,05). Hasil penelitian menunjukkan faktor yang berhubungan dengan kejadian ASD adalah usia ayah (p=0,03; OR=4,00; CI=1,250-12,804), riwayat stres saat hamil (p=0,04; OR=3,18; CI=1,13-8,93) dan lahir belum cukup bulan (p=0,036; OR=4,88; CI=1,22-19,4), sedangkan usia ibu saat hamil, perokok pasif, perdarahan antenatal dan jarak kehamilan tidak berhubungan dengan kejadian ASD (p>0,05). Simpulan penelitian ini adalah faktor usia ayah, adanya riwayat stres saat hamil dan kelahiran belum cukup bulan berhubungan dengan kejadian ASD.


Keyword : Usia ayah, riwayat stress, Autism Spectrum Disorder

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How to Cite
Hernawan, A., Diningrum, A., Jati, S., & Nasip, M. (2018). Risk Factors of Autism Spectrum Disorder (ASD). Unnes Journal of Public Health, 7(2), 104-112. https://doi.org/10.15294/ujph.v7i2.20565

References

Ganaie S.A., & Bashir, A. 2014. Global Autism : Autism, Autism Etiology, Perceptions, Epistemology, Prevalence and Action. International Journal of Clinical Therapeutics and Diagnosis, 2 (2): 39-47.
Arulita, S.D. 2014. Faktor Risiko Autisme (Studi Kasus di tempat terapi X dan SLB Y Kabupaten Jember 2014). Bachelor Scription. Jember: Universitas Jember.
Budi, L.P.R., Sitaresmi, M.N., & Windiyani, I.G.A.T. 2015. Paternal and Maternal Age at Pregnancy and Autism Spectrum Disorders in Offspring. Paediatrica Indonesiana, 55(6): 345-351.
Chamidah, A.N. 2009. Deteksi Dini Gangguan Pertumbuhan dan Perkembangan Anak. Jurnal Pendidikan Khusus, 5(2): 83-93.
Croen, L.A., Zerbo, O., Qian, Y., Massolo, M.L., Rich, S., Sidney, S., & Kripke, C. 2015. The Health Status of Adults on the Autism Spectrum. Autism: The International Journal of Research and Practice, 19(7): 814-823.
Elwardany, S., Ibrahim, H., Askar, G., & Bayomi, S. 2013. Risk Factors for Autistic Spectrum Disorders at Assiut City. Journal of Education and Practice, 4(28): 147-157.
Gardener, H., Spiegelman, D., & Buka, S.L. 2009. Prenatal Risk Factors for Autism : A Comprehensive Meta-analysis. The British Journal of Psychiatry, 195 (1): 7-14.
Goldin, R. 2015. Premature Birth as a Factor in Autism Spectrum Disorder. Thesis. Baton Rouge Louisiana: The Department of Psychology – Louisiana State University
H, Coo., H, O.K., M, Lam Y., M, Brownell., P, Flavin M., dan L, Roos L. 2015. The Association between The Interpregnancy Interval and Autism Spectrum Disorder in a Canadian Cohort. Canadian Journal of Public Health, 106 (2): 36-42.
Hanum, H. 2017. Pengaruh Paparan Asap Rokok Pada Ibu Hamil Terhadap Kejadian BBLR. Bachelor Scription. Lampung: Universitas Lampung
Hardiyanti, M.D. 2014. Faktor-faktor yang berpengaruh terhadap Luaran Maternal dan Perinatal Pada Ibu Hamil di Usia Tua. Bachelor Scription. Semarang: Universitas Diponegoro
Hultman, C.M., Sandin, S., Levine, S.Z., Lichtenstein, P., dan Reichenberg, A. 2011. Advancing Paternal Age and Risk of Autism. Molecular Psychiatry, 16 (12): 1203-1212.
Kinney, D. 2008. Prenatal Stress and Risk for Autism. NIH Neurosciences Biobehaviour, 32 (8): 1519-1532.
Ningrum, D. 2014. Hubungan Jarak Kehamilan dengan Kejadian Anemia pada Kehamilan di BPS Ny “U” Desa Sooko Kecamatan Sooko Kabupaten Mojokerto. Research Report. Jember: Universitas Jember
Nurbayatin, A., Sulistiawati., Sunjoto., & Puspitasari, D. 2015. Faktor Risiko yang Berpengaruh pada Periode Kehamilan, Persalinan dan Bayi Baru Lahir dengan Autisme. BIMABI, 3 (1): 1-6.
Salman, A., Malek, A., Amiri, S., Barzegar, H., & Rezaih, A.R. 2016. Stressful life events during pregnancy as risk factors of developing autistic disorder in children. Journal of Analytical Research in Clinical Medicine, 4(4): 207-214.
Sawitri, L. 2014. Hubungan Jarak Kehamilan dengan Kejadian Hemoragik Postpartum di Puskesmas Sumberbaru. The Journal of Midwifery,1 (3): 46-51.
Sibuea, Meyclin. 2013. Persalinan pada Usia ≥35 tahun di RSU Prof. Dr. R.D Kandou Manado. Jurnal e-Biomedik (eBM),1(1): 484-489.
Sinsin, I. 2008. Seri Kesehatan Ibu dan Anak Masa Kehamilan dan Persalinan. Jakarta: PT. Elex Media Komputindo
Suharningsih, 2015. Hubungan antara Pola Asuh dan Kepatuhan Diet Bebas Gluten Bebas Casein dengan Status Gizi Anak Autis di Kota Pontianak. JUMANTIK, (2): 1-8.
Sulistiarini. 2016. Faktor-faktor yang memengaruhi Kelahiran Prematur di Indonesia Analisis Data RISKESDAS 2013. E-Jurnal WIDYA Kesehatan dan Lingkungan,1(2): 109-115.
The New York Times. 2012. Father’s Age Linked to Autism and Schizophrenia. http://www.nytimes.com/2012/08/23/health/fathers-age-is-linked-to-risk-of-autism-and-schizophrenia.html?smid=pl-share. Diakses 7 April 2017
WHO. 2016. Autism Spectrum Disorders. www.who.int. Diakses 26 Maret 2016
Zahra, R.N.F. 2014. Faktor Risiko terjadinya Autism Spectrum Disorder. Bachelor Scription. Surabaya: Universitas Airlangga
Zhang, X., Lv, Cong Chao., Tian, Jiang., Miao, Ru-Juan., Xi, Wei., Hertz-Piccioto, I., & Qi, L. 2010. Prenatal and Perinatal Risk Factors for Autism in China. J Autism Dev Disorder, (40): 1311-1321.