COVID-19 Pandemic: The Existing Challenges and Available Solution; Evidence from a Systematic Review
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Abstract
Coronavirus disease (COVID-19) is presently the most important topic worldwide. However, no vaccine or specific anti-viral treatment for the disease has been shown to be effective. In this emergency, identifying risk factors, preventive measures and estimating challenges which control available drug options for COVID-19 are key to mitigating the severity of the pandemic until specific drugs or vaccines become available. Therefore, this study aims to identify possible factors which affect these drug options. This study searched PubMed database using necessary Boolean operators from December 31st to March 31st 2020 in order to identify common risk factors, preventive measures, information regarding control challenges & evidence on the available drug options against COVID-19. Risk factors were found to be human-animal interactions, males, aged people
and people with co-morbidity. Furthermore, protective factors comprised of personal hygiene etiquette maintenance, rapid identification, isolation and informing (3I tools) of the COVID-19 cases and media coverage on COVID-19. Till date, anti-viral drugs like remdesivir, chloroquine, lopinavir/ritonavir and traditional Chinese medicine (TCM) are available options to fight against COVID-19. More research is needed to determine other how to control the disease until specific treatment options are available as well as risk factors, and preventive measures.
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References
Anastassopoulou, C., Russo, L., Tsakris, A., & Siettos, C. 2020. Data-based Analysis, Modelling and Forecasting of the COVID-19 Outbreak. PLoS ONE, 15 (3), e0230405. https://doi.org/10.1371/journal.pone.0230405
Assiri, A., Al-Tawfiq, J. A., Al-Rabeeah, A. A., Al-Rabiah, F. A., Al-Hajjar, S., Al-Barrak, A., Flemban, H., Al-Nassir, W. N., Balkhy, H. H., Al-Hakeem, R. F., Makhdoom, H. Q., Zumla, A. I., & Memish, Z. A. 2013. Epidemiological, Demographic, and Clinical Characteristics of 47 Cases of Middle East Respiratory Syndrome Coronavirus Disease from Saudi Arabia: A Descriptive Study. The Lancet Infectious Diseases, 13 (9): 752–761. https://doi.org/10.1016/S1473-3099(13)70204-4
Backer, J. A., Klinkenberg, D., & Wallinga, J. 2020. Incubation Period of 2019 novel Coronavirus (2019-nCoV) Infections among Travellers from Wuhan, China, 20–28 January 2020. Eurosurveillance, 25 (5), 2000062. https://doi.org/10.2807/1560-7917.ES.2020.25.5.2000062
Bauch, C. T., & Oraby, T. 2013. Assessing the Pandemic Potential of MERS-CoV. The Lancet, 382 (9893): 662–664. Elsevier. https://doi.org/10.1016/S0140-6736(13)61504-4
Benvenuto, D., Giovanetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., & Ciccozzi, M. 2020. The 2019â€new Coronavirus Epidemic: Evidence for Virus Evolution. Journal of Medical Virology, 92 (4): 455–459. https://doi.org/10.1002/jmv.25688
Blendon, R. J., Koonin, L. M., Benson, J. M., Cetron, M. S., Pollard, W. E., Mitchell, E. W., Weldon, K. J., & Herrmann, M. J. 2008. Public Response to Community Mitigation Measures for Pandemic Influenza. Emerging Infectious Diseases Journal, 14 (5): pp. 778–786). https://doi.org/10.3201/eid1405.071437
Burke, R. M., Midgley, C. M., Dratch, A., Fenstersheib, M., Haupt, T., Holshue, M., Ghinai, I., Jarashow, M. C., Lo, J., McPherson, T. D., Rudman, S., Scott, S., Hall, A. J., Fry, A. M., & Rolfes, M. A. 2020. Active Monitoring of Persons Exposed to Patients with Confirmed COVID-19 - United States, January-February 2020. Morbidity and Mortality Weekly Report, 69 (9): 245–246. https://doi.org/10.15585/mmwr.mm6909e1
CDC. 2020a. Contact Tracing: Part of a Multipronged Approach to Fight the COVID-19 Pandemic. Retrieved April 29, 2020, from https://www.cdc.gov/coronavirus/2019-ncov/php/principles-contact-tracing.html
CDC. 2020b. People Who are at Higher Risk for Severe Illness. Retrieved April 29, 2020, from https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-at-higher-risk.html
CDC. 2020c. Zoonotic Diseases. One Health. Retrieved April 29, 2020, from https://www.cdc.gov/onehealth/basics/zoonotic-diseases.html
Chang, L., Yan, Y., & Wang, L. 2020. Coronavirus Disease 2019: Coronaviruses and Blood Safety. Transfusion Medicine Reviews, 34 (2): 75–80. https://doi.org/https://doi.org/10.1016/j.tmrv.2020.02.003
Channappanavar, R., Fett, C., Mack, M., Ten Eyck, P. P., Meyerholz, D. K., & Perlman, S. 2017. Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection. Journal of Immunology, 198 (10): 4046–4053. https://doi.org/10.4049/jimmunol.1601896
Chen, J. 2020. Pathogenicity and Transmissibility of 2019-nCoV—A Quick Overview and Comparison with Other Emerging Viruses. Microbes and Infection, 22 (2): 69–71. https://doi.org/10.1016/j.micinf.2020.01.004
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. 2020. Epidemiological and Clinical Characteristics of 99 Cases of 2019 Novel Coronavirus Pneumonia in Wuhan, China: a Descriptive Study. The Lancet, 395 (10223): 507–513. https://doi.org/10.1016/S0140-6736(20)30211-7
Chen, T., Wu, D., Chen, H., Yan, W., Yang, D., Chen, G., Ma, K., Xu, D., Yu, H., Wang, H., Wang, T., Guo, W., Chen, J., Ding, C., Zhang, X., Huang, J., Han, M., Li, S., Luo, X., … Ning, Q. 2020a. Clinical Characteristics of 113 Deceased Patients with Coronavirus Disease 2019: Retrospective Study. BMJ (Clinical Research Ed.), 368. m1091. https://doi.org/10.1136/bmj.m1091
Chen, T., Wu, D., Chen, H., Yan, W., Yang, D., Chen, G., Ma, K., Xu, D., Yu, H., Wang, H., Wang, T., Guo, W., Chen, J., Ding, C., Zhang, X., Huang, J., Han, M., Li, S., Luo, X., … Ning, Q. 2020b. Clinical Characteristics of 113 Deceased Patients with Coronavirus Disease 2019: Retrospective Study. BMJ, 368. https://doi.org/10.1136/bmj.m1091
Delamater, P. L., Street, E. J., Leslie, T. F., Yang, Y. T., & Jacobsen, K. H. 2019. Complexity of the Basic Reproduction Number (R0). Emerging Infectious Diseases, 25 (1): 1–4. https://doi.org/10.3201/eid2501.171901
Dexler, M. 2010. What You Need to Know About Infectious Disease-NCBI Bookshelf. Washingto D.C: National Academic Press. Retrieved April 29, 2020, from https://www.ncbi.nlm.nih.gov/books/NBK209704/
Dong, L., Hu, S., & Gao, J. 2020. Discovering Drugs to Treat Coronavirus Disease 2019 (COVID-19). Drug Discoveries & Therapeutics, 14 (1): 58–60. https://doi.org/10.5582/ddt.2020.01012
Du, H. Z., Hou, X. Y., Miao, Y. H., Huang, B. S., & Liu, D. H. 2020. Traditional Chinese Medicine: an Effective Treatment for 2019 Novel Coronavirus Pneumonia (NCP). In Chinese Journal of Natural Medicines, 18 (3): 206–210. China Pharmaceutical University. https://doi.org/10.1016/S1875-5364(20)30022-4
Ekins, S., Lane, T. R., & Madrid, P. B. 2020. Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond. Pharmaceutical Research, 37 (4): 1–8. https://doi.org/10.1007/s11095-020-02799-8
Elfiky, A. A. 2020. Anti-HCV, Nucleotide Inhibitors, Repurposing Against COVID-19. Life Sciences, 248, 117477. https://doi.org/10.1016/j.lfs.2020.117477
Fedson, D. S., Opal, S. M., & Rordam, O. M. 2020. Hiding in Plain Sight: An Approach to Treating Patients with Severe Covid-19 Infection. MBio, 11 (2). https://doi.org/10.1128/mBio.00398-20
Fehr, A. R., Channappanavar, R., & Perlman, S. 2017. Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus. Annual Review of Medicine, 68 (1): 387–399. https://doi.org/10.1146/annurev-med-051215-031152
Fowler, R. A., Guest, C. B., Lapinsky, S. E., Sibbald, W. J., Louie, M., Tang, P., Simor, A. E., & Stewart, T. E. 2004. Transmission of Severe Acute Respiratory Syndrome during Intubation and Mechanical Ventilation. American Journal of Respiratory and Critical Care Medicine, 169 (11): 1198–1202. https://doi.org/10.1164/rccm.200305-715oc
Ghinai, I., McPherson, T. D., Hunter, J. C., Kirking, H. L., Christiansen, D., Joshi, K., et al. 2020. First Known Person-to-Person Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the USA. The Lancet, 395 (10230): 1137–1144. https://doi.org/10.1016/S0140-6736(20)30607-3
Gralinski, L. E., & Menachery, V. D. 2020. Return of the Coronavirus: 2019-nCoV. Viruses, 12 (2): 135. https://doi.org/10.3390/v12020135
Haider, N., Yavlinsky, A., Simons, D., Osman, A. Y., Ntoumi, F., Zumla, A., & Kock, R. 2020. Passengers’ Destinations from China: Low Risk of Novel Coronavirus (2019-nCoV) Transmission into Africa and South America. Epidemiology and Infection, 148. https://doi.org/10.1017/S0950268820000424
Han, M. A. 2018. Hand Hygiene and Tuberculosis Risk in Korea: An Ecological Association. Asia Pacific Journal of Public Health, 30 (1): 67–74. https://doi.org/10.1177/1010539517751746
Hellewell, J., Abbott, S., Gimma, A., Bosse, N. I., Jarvis, C. I., Russell, T. W., et al. 2020. Feasibility of Controlling COVID-19 Outbreaks by Isolation of Cases and Contacts. The Lancet Global Health, 8 (4): e488–e496. https://doi.org/10.1016/S2214-109X(20)30074-7
Hua, J., & Shaw, R. 2020. Corona Virus (Covid-19) “Infodemic†and Emerging Issues through a Data Lens: The Case of China. International Journal of Environmental Research and Public Health, 17 (7): 2309. https://doi.org/10.3390/IJERPH17072309
Huang, R., Liu, M., & Ding, Y. 2020. Spatial-temporal Distribution of COVID-19 in China and its Prediction: A Data-driven Modeling Analysis. Journal of Infection in Developing Countries, 14 (3): 246–253. https://doi.org/10.3855/jidc.12585
Jaillon, S., Berthenet, K., & Garlanda, C. 2019. Sexual Dimorphism in Innate Immunity. In Clinical Reviews in Allergy and Immunology, 56 (3): 308–321. https://doi.org/10.1007/s12016-017-8648-x
Khan, S., Nabi, G., Han, G., Siddique, R., Lian, S., Shi, H., Bashir, N., Ali, A., & Shereen, M. A. 2020. Novel Coronavirus: How Things are in Wuhan. In Clinical Microbiology and Infection, 26 (4): 399–400. https://doi.org/10.1016/j.cmi.2020.02.005
Kickbusch, I., & Leung, G. 2020. Response to the Emerging Novel Coronavirus Outbreak. In The BMJ, 368. https://doi.org/10.1136/bmj.m406
Koenig, K., Bey, C., & McDonald, E. 2020. 2019-nCoV: The Identify-Isolate-Inform (3I) Tool Applied to a Novel Emerging Coronavirus. Western Journal of Emergency Medicine, 21 (2): 184–190. https://doi.org/10.5811/westjem.2020.1.46760
Leung, N. H. L., Chu, D. K. W., Shiu, E. Y. C., Chan, K.-H., McDevitt, J. J., Hau, B. J. P., et al. 2020. Respiratory Virus Shedding in Exhaled Breath and Efficacy of Face Masks. Nature Medicine, 1–5. https://doi.org/10.1038/s41591-020-0843-2
Li, H.-Y., Zhu, G.-J., Zhang, Y.-Z., Zhang, L.-B., Hagan, E. A., Martinez, S., et al. 2020. A Qualitative Study of Zoonotic Risk Factors among Rural Communities in Southern China. International Health, 12 (2): 77–85. https://doi.org/10.1093/inthealth/ihaa001
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., et al. 2020. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. New England Journal of Medicine, 382 (13): 1199–1207. https://doi.org/10.1056/NEJMoa2001316
Li, T. 2020. Diagnosis and Clinical Management of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: an Operational Recommendation of Peking Union Medical College Hospital (V2.0)--Working Group of 2019 Novel Coronavirus. In Emerging Microbes and Infections, 9 (1): 582–585. https://doi.org/10.1080/22221751.2020.1735265
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., et al. 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (Clinical Research Ed.), 339. https://doi.org/10.1136/bmj.b2700
Lim, J., Jeon, S., Shin, H. Y., Kim, M. J., Seong, Y. M., Lee, W. J., et al. 2020. Case of the Index Patient who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: The Application of Lopinavir/ Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR. Journal of Korean Medical Science, 35 (6). https://doi.org/10.3346/jkms.2020.35.e79
Liu, Y., Gayle, A. At. 2020. Reproductive Number of C.-19 is Higher Compared to S. Coronavirus, Wilder-Smith, A., & Rocklöv, J. The reproductive number of COVID-19 is higher compared to SARS coronavirus. Journal of Travel Medicine, 27 (2). https://doi.org/10.1093/jtm/taaa021
Lu, H. 2020. Drug Treatment Options for the 2019-New Coronavirus (2019-nCoV). BioScience Trends, 14 (1). https://doi.org/10.5582/BST.2020.01020
Lu, S. 2020. Timely Development of Vaccines Against SARS-CoV-2. In Emerging Microbes and Infections, 9 (1): 542–544. https://doi.org/10.1080/22221751.2020.1737580
Mizumoto, K., Kagaya, K., Zarebski, A., & Chowell, G. 2020. Estimating the Asymptomatic Proportion of Coronavirus Disease 2019 (COVID-19) Cases on Board the Diamond Princess Cruise Ship, Yokohama, Japan, 2020. In Eurosurveillance, 25 (10). https://doi.org/10.2807/1560-7917.ES.2020.25.10.2000180
Morse, J. S., Lalonde, T., Xu, S., & Liu, W. R. 2020. Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019â€nCoV. ChemBioChem, 21 (5): 730–738. https://doi.org/10.1002/cbic.202000047
Ng, Y., Li, Z., Chua, Y. X., Chaw, W. L., Zhao, Z., Er, B., et al. 2020. Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore - January 2-February 29, 2020. Morbidity and Mortality Weekly Report, 69 (11): 307–311. https://doi.org/10.15585/MMWR.MM6911E1
Pan, X., Chen, D., Xia, Y., Wu, X., Li, T., Ou, X., Zhou, L., & Liu, J. 2020. Asymptomatic Cases in a Family Cluster with SARS-CoV-2 Infection. The Lancet Infectious Diseases, 20 (4): 410–411. https://doi.org/10.1016/S1473-3099(20)30114-6
Parrish, C. R., Holmes, E. C., Morens, D. M., Park, E.-C., Burke, D. S., Calisher, C. H., Laughlin, C. A., Saif, L. J., & Daszak, P. 2008. Cross-Species Virus Transmission and the Emergence of New Epidemic Diseases. Microbiology and Molecular Biology Reviews, 72 (3): 457–470. https://doi.org/10.1128/mmbr.00004-08
Peeri, N. C., Shrestha, N., Rahman, M. S., Zaki, R., Tan, Z., Bibi, S., Baghbanzadeh, M., Aghamohammadi, N., Zhang, W., & Haque, U. 2020. The SARS, MERS and Novel Coronavirus (COVID-19) Epidemics, the Newest and Biggest Global Health Threats: what Lessons have We Learned? International Journal of Epidemiology, 49 (3): 717–726. https://doi.org/10.1093/ije/dyaa033
Pung, R., Chiew, C. J., Young, B. E., Chin, S., Chen, M. I. C., Clapham, H. E., et al. 2020. Investigation of Three Clusters of COVID-19 in Singapore: Implications for Surveillance and Response Measures. The Lancet, 395 (10229): 1039–1046. https://doi.org/10.1016/S0140-6736(20)30528-6
Quilty, B. J., Clifford, S., Flasche, S., & Eggo, R. M. 2020. Effectiveness of Airport Screening at Detecting Travellers Infected with Novel Coronavirus (2019-nCoV). In Eurosurveillance, 25 (5). https://doi.org/10.2807/1560-7917.ES.2020.25.5.2000080
Raboud, J., Shigayeva, A., McGeer, A., Bontovics, E., Chapman, M., Gravel, D., et al. 2010. Risk Factors for SARS Transmission from Patients Requiring Intubation: A Multicentre Investigation in Toronto, Canada. PLoS ONE, 5 (5), e10717. https://doi.org/10.1371/journal.pone.0010717
Rahman, A., & Sarkar, A. 2019. Risk Factors for Fatal Middle East Respiratory Syndrome Coronavirus Infections in Saudi Arabia: Analysis of the WHO Line List, 2013-2018. American Journal of Public Health, 109 (9): 1288–1293. https://doi.org/10.2105/AJPH.2019.305186
Rasmussen, S. A., Smulian, J. C., Lednicky, J. A., Wen, T. S., & Jamieson, D. J. 2020. Coronavirus Disease 2019 (COVID-19) and Pregnancy: What Obstetricians Need to Know. American Journal of Obstetrics & Gynecology, 222 (5): 415–426. https://doi.org/10.1016/j.ajog.2020.02.017
Rong, X., Yang, L., Chu, H., & Fan, M. 2020. Effect of Delay in Diagnosis on Transmission of COVID-19. Mathematical Biosciences and Engineering, 17 (3): 2725–2740. https://doi.org/10.3934/mbe.2020149
ScienceDaily. 2020. COVID-19 Coronavirus Epidemic has a Natural Origin. Retrieved April 3, 2020 from https://www.sciencedaily.com/releases/2020/03/200317175442.htm
Shi, Y., Yu, X., Zhao, H., Wang, H., Zhao, R., & Sheng, J. 2020. Host Susceptibility to Severe COVID-19 and Establishment of a Host Risk Score: Findings of 487 Cases Outside Wuhan. Critical Care, 24 (1). https://doi.org/10.1186/s13054-020-2833-7
Stower, H. 2020. Lopinavir–Ritonavir in Severe COVID-19. Nature Medicine, 26 (4), 465. https://doi.org/10.1038/s41591-020-0849-9
Thompson, R. 2020. Pandemic Potential of 2019-nCoV. In The Lancet Infectious Diseases, 20 (3): 280. https://doi.org/10.1016/S1473-3099(20)30068-2
Tian, S., Hu, N., Lou, J., Chen, K., Kang, X., Xiang, Z., et al. 2020. Characteristics of COVID-19 Infection in Beijing. Journal of Infection, 80 (4): 401–406. https://doi.org/10.1016/j.jinf.2020.02.018
Wang, C., Pan, R., Wan, X., Tan, Y., Xu, L., Ho, C. S., & Ho, R. C. 2020. Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. International Journal of Environmental Research and Public Health, 17 (5). https://doi.org/10.3390/ijerph17051729
Wang, F. S., & Zhang, C. 2020. What to do Next to Control the 2019-nCoV Epidemic? In The Lancet, 395 (10222): 391–393. https://doi.org/10.1016/S0140-6736(20)30300-7
Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., et al. 2020. Remdesivir and Chloroquine Effectively Inhibit the Recently Emerged Novel Coronavirus (2019-nCoV) in Vitro. In Cell Research, 30 (3): 269–271. Springer Nature. https://doi.org/10.1038/s41422-020-0282-0
Wang, Z., Chen, X., Lu, Y., Chen, F., & Zhang, W. 2020. Clinical Characteristics and Therapeutic Procedure for Four Cases with 2019 Novel Coronavirus Pneumonia Receiving Combined Chinese and Western Medicine Treatment. BioScience Trends, 14 (1): 64–68. https://doi.org/10.5582/bst.2020.01030
WHO. 2020a. Modes of Transmission of Virus Causing COVID-19: Implications for IPC Precaution Recommendations. Retrieved April 29, 2020, from https://www.who.int/news-room/commentaries/detail/modes-of-transmission-of-virus-causing-covid-19-implications-for-ipc-precaution-recommendations
WHO. 2020b. Q&A on Coronaviruses (COVID-19). Retrieved April 29, 2020, from https://www.who.int/news-room/q-a-detail/q-a-coronaviruses
WHO. 2020c. WHO COVID-19 Dashboard. Retrieved April 29, 2020, from https://covid19.who.int/
Wilder-Smith, A., & Freedman, D. O. 2020. Isolation, Quarantine, Social Distancing and Community Containment: Pivotal Role for Old-Style Public Health Measures in the Novel Coronavirus (2019-nCoV) Outbreak. Journal of Travel Medicine, 27 (2). https://doi.org/10.1093/jtm/taaa020
Wu, A., Peng, Y., Huang, B., Ding, X., Wang, X., Niu, P., et al. 2020. Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. Cell Host and Microbe, 27 (3): 325–328. https://doi.org/10.1016/j.chom.2020.02.001
Xiao, Y., Tang, S., & Wu, J. 2015. Media Impact Switching Surface during an Infectious Disease Outbreak. Scientific Reports, 5 (1): 1–9. https://doi.org/10.1038/srep07838
Yang, C., & Wang, J. 2020. A Mathematical Model for the Novel Coronavirus Epidemic in Wuhan, China. Mathematical Biosciences and Engineering, 17 (3): 2708–2724. https://doi.org/10.3934/mbe.2020148
Yang, W., Cao, Q., Qin, L., Wang, X., Cheng, Z., Pan, A., et al. 2020. Clinical Characteristics and Imaging Manifestations of the 2019 Novel Coronavirus Disease (COVID-19): A Multi-Center Study in Wenzhou City, Zhejiang, China. Journal of Infection, 80 (4): 388–393. https://doi.org/10.1016/j.jinf.2020.02.016
Yu, X., & Yang, R. 2020. COVID-19 Transmission through Asymptomatic Challenge to Containment. Influenza and Other Respiratory Viruses, 14 (4): 474-475. https://doi.org/10.1111/irv.12743
Zhang, D. Hai, Wu, K. lun, Zhang, X., Deng, S. Qiong, & Peng, B. 2020. In Silico Screening of Chinese Herbal Medicines with the Potential to Directly Inhibit 2019 Novel Coronavirus. Journal of Integrative Medicine, 18 (2): 152–158. https://doi.org/10.1016/j.joim.2020.02.005
Zhang, G., Zhang, J., Wang, B., Zhu, X., Wang, Q., & Qiu, S. 2020. Analysis of Clinical Characteristics and Laboratory Findings of 95 Cases of 2019 Novel Coronavirus Pneumonia in Wuhan, China: A Retrospective Analysis. Respiratory Research, 21 (1): 74. https://doi.org/10.1186/s12931-020-01338-8
Zhao, S., Lin, Q., Ran, J., Musa, S. S., Yang, G., Wang, W., et al. 2020. Preliminary Estimation of the Basic Reproduction Number of Novel Coronavirus (2019-nCoV) in China, from 2019 to 2020: A Data-driven Analysis in the Early Phase of the Outbreak. International Journal of Infectious Diseases, 92: 214–217. https://doi.org/10.1016/j.ijid.2020.01.050
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., et al. 2020. Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: a Retrospective Cohort Study. The Lancet, 395 (10229): 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3
Zhou, W., Wang, A., Xia, F., Xiao, Y., & Tang, S. 2020. Effects of media reporting on mitigating spread of COVID-19 in the early phase of the outbreak. Mathematical Biosciences and Engineering, 17(3), 2693–2707. https://doi.org/10.3934/mbe.2020147